Kumoro, A.C. and Hasan, M. (2006) EFFECT OF SOLVENT FLOW RATE ON THE SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF ANDROGRAPHOLIDE FROM ANDROGRAPHIS PANICULATA. In: 11th Asia Pacific Confederation Chemical Engineering Conference 2006, 27-30August 2006, Kuala Lumpur, MALAYSIA.
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Malaysia is one of the major medicinal plants (Andrographis paniculata) producers in the world. Extraction of bioactive component (andrographolide) from ground dried leaves of this plant using supercritical carbon dioxide has been studied. The effect of solvent flow rates ranging from 7.95 × 10-6 to 6.36 × 10-5 kg/s on the extraction efficiency has been investigated. The extraction yield increased with the increase of solvent flow rate from 7.95 × 10-6 to 3.18 × 10-5 kg/s. However further increase of solvent flow rate reduced the extraction yield. Therefore, an optimum solvent flow rate at 3.18 × 10-5 kg/s was obtained for the system under study. The extraction process was found to be controlled by intraparticle diffusion of the andrographolide in the starting leaves particles.
|Item Type:||Conference or Workshop Item (Paper)|
|Uncontrolled Keywords:||solvent, flow rate, supercritical carbon dioxide, extraction, andrographolide|
|Subjects:||S Agriculture > S Agriculture (General)|
T Technology > TP Chemical technology
Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
|Divisions:||Faculty of Engineering > Department of Chemical Engineering|
Faculty of Engineering > Department of Chemical Engineering
|Deposited By:||Dr. Andri Kumoro|
|Deposited On:||03 Jun 2009 12:17|
|Last Modified:||03 Jun 2009 12:19|
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