MANIFESTASI KLINIS DAN LABORATORIS GANGGUAN PERDARAHAN PADA PENDERITA LEPTOSPIROSIS BERAT

Abstract

Background: Haemorrhagic disorders are prominent clinical manifestation in severe leptospirosis but its patophysiology is still not clear. Haemorrhagic complication could be detected from clinical appearances and laboratory findings that specific in thrombohaemorrhagic syndrome. The aim of this study was to know about clinical and laboratory manifestations of haemorrhagic disorders in severe leptospirosis patient. Methods: This was an observational descriptive study with cross sectional design. The data were taken from SEALS (Semarang Amsterdam Leptospirosis Studies) case record forms by selected some variables as follows: petechiae, haematuria, haematoschezia, melaena, haematemesis, epystaxis, gum bleeding, haemoptysis, platelet count, prothrombin time, activated partial thromboplastin time. Results: The most clinical appearance of haemorrhagic disorders in severe leptospirosis is petechiae which found in 17 of 112 patients (15,2%), the other clinical manifestations that found in this research are haematuria (0,9%), haematoschezia (0,9%), melaena (0,9%), and haematemesis (1,8%). The common laboratory findings in severe leptospirosis is thrombocytopenia which found in 86 patients (82,7%), prolonged PTT which found in 28 patients (53,8%), and normal aPTT which found in 27 patients (52,9%). Conclusions: The most common haemorrhagic manifestation of patients with severe leptospirosis was petechiae. Thrombocytopenia, prolonged PTT and normal aPTT were frequently found in this study. Keywords:clinical manifestations, haemorrhagic disorders, severe leptospirosis