PENGARUH PEMBERIAN PROPOXUR DOSIS BERTINGKAT PER ORAL TERHADAP GAMBARAN HISTOPATOLOGIS PARU-PARU MENCIT BALB/C

Abstract

Background: Although it has been well-known that propoxur can make respiratory depression, the propoxur effect in the lungs is still not clear. Objective: My purpose was to value the correlation of histopathological appearance on Balb/c mice lungs with oral administration of multilevel doses Propoxur. Methods: Data were achieved after observing each groups: Control group, P1 group, P2 group, and P3 group, a post test only control group study of experiment. Results: There were significant differences between groups (p = 0,000), but neither P1 group – P2 group (p = 0,108) nor P2 group – P3 group (p = 0,100) nor P3 group – P1 group (p = 0,746) showed any significant difference of the changes of histopathological appearances of Balb/c mice lungs. Limitations: My results are based on subjective observer sight. Conclusion: Propoxur caused histopathological appearances of Balb/c mice lungs change, but there was no significant changes in administering multilevel doses. Keywords: propoxur, multilevel doses, histopathology of lungs.