PENGARUH PEMBERIAN TEH KOMBUCHA DOSIS BERTINGKAT PER ORAL TERHADAP GAMBARAN HISTOLOGI GINJAL MENCIT BALB/C

Abstract

Background: Kombucha tea is a traditional medicine used empirically by Indonesian people to treat diseases or to maintain their health. In the body, Kombucha tea will be absorbed, distributed, metabolized and excreted. Kidney is the primary organ of excretion, as it can be damaged by toxic substances. The purpose of this experiment was to evaluate the changes of histological appearance of Balb/c mice’s kidney after the administration of gradual doses of Kombucha tea for 35 days. Method : The research study used the post test only control group design. The sample were 20 Balb/c mice with specific criteria and randomized into 4 groups. The Control group (K) received water only, while group P1, P2, P3 were given Kombucha tea in gradual doses orally in 35 days 2x/day, respectively 0.26ml, 0.39ml, 0.52ml. The target was the summary of the proximal tubule’s space which closed. Results: There were proximal tubule damages i.e closing of the proximal tubule’s space in group P1-3. One Way ANOVA test showed the significantly differences in all groups (p<0.05). Post Hoc test showed the significant differences (p<0.05) in all groups : K-P1 (p=0.0000); K-P2 (p=0.000); K-P3 (p=0.000); P1-P2 (p=0.000); P1-P3 (p=0.000); P2-P3 (p=0.000). Conclusion: There were significant differences on the histological appearance of mice’s kidney, between groups which was given Kombucha tea with the groups which was not, in accordance with the increasing doses. Keyword: Kombucha tea, The Kidney histological appearance, Balb/c mice.