PENGARUH PEMBERIAN Curcuma domestica TERHADAP GAMBARAN HISTOLOGI HEPAR MENCIT BALB/C YANG DIBERI PARASETAMOL

Abstract

Background : Kunyit (Curcuma domestica) is a traditional herbal medicine used by a lot of people in our society. Previous research proved that it can be used for anti inflamation , anti oxidant, and anti cancer. Kunyit will be biotransformating in liver. Paracetamol is an analgetic and antipyretic medicine which have been used for self medication. Over dosage of this medicine potentially damage the liver. Liver is major detoxification organ which oftenly damaged marked by histological structural changes. Objective : To prove the effect of Kunyit for liver histological appearance on Balb/c mice which gave paracetamol. Methods : Experimental studies the post test only control group design, with 36 sample of mice strain balb/c (18 male, 18 female). Devide in 6 group randomly, it is group control (K) : without treatment. Group P1 gave paracetamol in 3,5 mg/days. Group P2 gave kunyit extract in 3 mg/days. Group P3 gave kunyit extract in 3 mg/days and then they gave paracetamol in 3,5 mg/days. Group P4 gave kunyit extract in 6 mg/days and then gave paracetamol in 3,5 mg/days. Group P5 gave kunyit extract in 12 mg/days and then gave paracetamol in 3,5 mg/days. Result : There was histological appearance changes; parenchymatous degeneration on K, P1, P2, P3, P4; hidropic degeneration on P1, P2, P3, P4, P5; and necrosis on P5. P4 showed less liver damage than P3. The test showed significant difference (p ≤ 0.05) from each groups except on K-P1, P1-P2, P1-P4, P2-P4, P3-P4, P3-P5, P4-P5. Conclucion : Kunyit not impede liver damage on Balb/c mice which induced parasetamol. Keyword : Kunyit (Curcuma domestica), paracetamol, liver, parenchymatous degeneration, hidropic degeneration, necrosis.