PENGARUH EKSTRAK KUNYIT (Curcuma domestica) TERHADAP GAMBARAN MIKROSKOPIK MUKOSA LAMBUNG MENCIT BALB/c YANG DIBERI PARASETAMOL

Abstract

Background : Turmeric (Curcuma domestica) as a traditional remedy,in research turmeric extract has gastroprotective effect. Paracetamol is regarded as a relatively safe drug in the gastro-duodenal region of humans but recent researchs have suggested that at high doses there may be an increased risk of ulcers. Objective : The aim of this study was to prove the role of turmeric’s extract to protect BALB/c mice gastric mucosa from damage induced by paracetamol. Methods : This research was experimental using the post test only control group design, 36 BALB/c mice which were devided into 6 groups. Group K received standard food. P1 everyday received paracetamol 3.5 mg on 7 days. P2 everyday received turmeric’s extract 3 mg on 14 days. P3, P4, and P5 received turmeric’s extract 3 mg, 6 mg, and 12 mg on 14 day and after its, each everydays received paracetamol 3.5 mg on 7 days after that. Results : P1 showed gastric mucosa irritation with a significant difference compared to control group. P2 is not significant difference compared to control group. P3 and P4 have showed an influence in protection against paracetamol but not significant difference compared to group P1. P5 received turmeric’s extract 12 mg and than paracetamol has an influence in protection against paracetamol. Conclusion : Turmeric’extract has an influence in protection against paracetamol-induced gastric mucosa damages in BALB/c mice, with the prominent effect in dose 12mg/day. Keywords : Turmeric’s extract (Curcuma domestica), gastric mucosa, Paracetamol.