PENGARUH PEMBERIAN EKSTRAK DAUN SALAM (Eugenia polyantha) TERHADAP KADAR HDL KOLESTEROL SERUM TIKUS JANTAN GALUR WISTAR HIPERLIPIDEMIA

Abstract

Background : Eugenia polyantha is one of nine best Indonesian medical plants because it has a lot of benefits. One of them is that it has been used as antihyperlipidemic agents for a long time. Eugenia polyantha contains several active regiments that has been considered to be able to increase HDL cholesterol serum level, so it may prevent hiperlipidemic condition. Because of that, a study to determine the effect of stratified dose of Eugenia polyantha extract on HDL cholesterol serum level in hyperlipidemic rats was done. Methoda : An experimental study using control group with Pre and Post Randomized Controlled Group Design was carried out to already made hyperlipidemic Wistar rats. Samples which consist of 28 male Wistar rats were divided into 4 groups. They are one control group, receive standard diet plus aquadest and three treatment group, given diet containing Eugenia polyantha extract from 0.18 gram fresh leaves of Eugenia polyantha for treatment I, 0.36 gram fresh leaves of Eugenia polyantha for treatment II, and 0.72 gram fresh leaves Eugenia polyantha for treatment III per day for 15 days. HDL Cholesterol serum level was determined using Precipitation of LDL, VLDL and chylomicrons. Data were analyzed using Wilcoxon methode for within subject data and Kruskal-Wallis methode for between subject data. The statistical analysis was done with SPSS program for windows ver 15.00. The difference is significant when p<0,05. Result : The administration of three dosage of Eugenia polyantha extract was significantly (p=0.000) increase the HDL cholesterol serum level. The higher the dosage was given would more increase the HDL cholesterol serum level. Conclusion : The administration of Eugenia polyantha extract from 0.18gr, 0.36gr, and 072gr fresh leaves of Eugenia polyantha/day can significantly increase the HDL cholesterol serum level in hyperlipidemic male Wistar rats. The higher the dosage was given the higher HDL cholesterol serum level was increased. Keyword : Hyperlipidemic, HDL Cholesterol, Eugenia polyantha extract.