PENGARUH PEMBERIAN ETOMIDATE TERHADAP KADAR GULA DARAH PASCA INDUKSI ANESTESI THE EFFECT OF ETOMIDATE ADMINISTRATION ON BLOOD GLUCOSE POST ANESTHESIA INDUCTION

Riffayadi, Odi (2010) PENGARUH PEMBERIAN ETOMIDATE TERHADAP KADAR GULA DARAH PASCA INDUKSI ANESTESI THE EFFECT OF ETOMIDATE ADMINISTRATION ON BLOOD GLUCOSE POST ANESTHESIA INDUCTION. Masters thesis, UNIVERSITAS DIPONEGORO.

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Abstract

ABSTRAK Latar belakang : Kekhawatiran etomidate menyebabkan hipoglikemi menjadi masalah. Onset aksi cepat, profil kardiovaskular rendah dan kurang signifikan menyebabkan penurunan tekanan darah membuat etomidate menjadi pilihan obat anestesi induksi yang cukup baik. Tujuan : Membuktikan pengaruh pemberian etomidate dalam menyebabkan penurunan kadar gula darah. Metode : Merupakan penelitian pretest posttest controlled group design pada 40 pasien yang menjalani operasi dengan anestesi umum, dibagi menjadi 2 kelompok (n=20), kelompok 1, etomidate 0,2 mg/kg (E2) dan kelompok 2, etomidate 0,4 mg/kg (E4). Masing – masing kelompok diperiksa kadar gula darah sebelum, 2 jam dan 6 jam sesudah induksi. Uji statistik pair T-test dan Wilcoxon rank sum test terhadap E2 dan E4. Hasil : Pada E 2 terdapat perbedaan bermakna P=0,05 antara sebelum dan 2 jam sesudah perlakuan 106,95 ± 15,453 mg/dl - 96,40 ± 14,966 mg/dl; 2 jam dan 6 jam sesudah perlakuan P=0,016; 96,40 ± 14,966 mg/dl - 108,85 ± 27,238 mg/dl. Sedangkan pada E 4 terdapat perbedaan bermakna P=0,041 baik sebelum dan 2 jam sesudah 102,60 ± 12,696 mg/dl - 99,35 ± 15,938 mg/dl; sebelum dan 6 jam sesudah P=0,041; 102,60 ± 12,696 mg/dl - 98,25 ± 19,878 mg/dl; maupun 2 jam dan 6 jam sesudah perlakuan P=0,041; 99,35 ± 15,938 mg/dl - 98,25 ± 19,878 mg/dl. Tetapi tidak terdapat perbedaan bermakna antara E2 dan E4 dalam menyebabkan penurunan kadar gula darah baik 2 jam P=0,550; 96,40 ± 14,966 mg/dl - 99,35 ± 15,938 mg/dl, maupun sesudah 6 jam pemberian P=0,104; 108,85 ± 27,238 mg/dl - 98,25 ± 19,878 mg/dl. Secara statistik etomidate menurunkan kadar gula darah baik pada E2 maupun E4 tetapi masih dalam batas normal atau secara klinik tidak bermakna. Kesimpulan : Etomidate 0,2 mg/kg (E2) dan 0,4 mg/kg (E4) secara statistik bermakna menurunkan kadar gula darah pada 2 jam dan 6 jam sesudah induksi,tetapi secara klinis tidak bermakna. Sedangkan E4 tidak terbukti lebih menurunkan kadar gula darah lebih besar dibandingkan E2. Kata kunci : Etomidate, supresi adrenal, kadar gula darah. xx ABSTRACT Background : The apprehensiveness of etomidate that causing hypoglicaemia becomed problem. A rapid onset of action, a low cardiovascular risk profile, and less likely to cause a significant drop in blood pressure provide etomidate choose an anesthetic induction drug. Objective : To proved the usage effects of etomidate that causing decrement of blood glucose level. Method : Pretest posttest controlled group design on 40 patients who are undergoing surgery with general anesthesia, divided into two groups (n=20), group E2 and E4, which received etomidate 0,2 mg/kgbw and 0,4 mg/kgbw respectively. Each group was examined its blood glucose 3 times, before, 2 hours, and 6 hours after induction. All data in E2 and E4 were analyzed by paired T-test and Wilcoxon rank sum test. Result : Blood glucose of E2 were significantly different P=0,05 between before and 2 hours after intervention 106,95 ± 15,453 mg/dl - 96,40 ± 14,966 mg/dl; between 2 hours and 6 hours after intervention P=0,016; 96,40 ± 14,966 mg/dl - 108,85 ± 27,238 mg/dl.While blood glucose of E4 were significantly different P=0,041 between before and 2 hours after intervention 102,60 ± 12,696 mg/dl - 99,35 ± 15,938 mg/dl;between before and 6 hours after intervention P=0,041; 102,60 ± 12,696 mg/dl - 98,25 ± 19,878 mg/dl; and between 2 hours and 6 hours after intervention P=0,041;99,35 ± 15,938 mg/dl-98,25 ± 19,878 mg/dl. However, there were no significant differences between E2 and E4 in decreasing blood glucose on 2 hours P=0,550; 96,40 ± 14,966 mg/dl - 99,35 ± 15,938 mg/dl and 6 hours after intervention P=0.104;108,85 ± 27,238 mg/dl - 98,25 ± 19,878 mg/dl. Statistically, etomidate could caused decrement on blood glucose, both in group E2 and E4 but still in normal border or clinically insignificant. Conclusion : Etomidate 0,2 mg/kgbw (E2) and 0,4 mg/kgbw (E4) were statistically significant in decreasing blood glucose on 2 hours and 6 hours after induction but clinically insignifican. While E4 were not decreasing blood glucose higher than E2. Keywords : Etomidate, adrenal suppression, blood glucose

Item Type:Thesis (Masters)
Subjects:R Medicine > R Medicine (General)
Divisions:Postgraduate Program > Master Program in Biomedical Science
ID Code:24045
Deposited By:Mr UPT Perpus 2
Deposited On:18 Nov 2010 09:43
Last Modified:18 Nov 2010 09:43

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