KADAR VITAMIN E RENDAH SEBAGAI FAKTOR RISIKO PENINGKATAN BILIRUBIN SERUM PADA NEONATUS THE LOW LEVEL OF VITAMIN E AS A RISK FACTOR OF INCREASING SERUM BILIRUBIN IN NEONATES

Sareharto, Tun Paksi (2010) KADAR VITAMIN E RENDAH SEBAGAI FAKTOR RISIKO PENINGKATAN BILIRUBIN SERUM PADA NEONATUS THE LOW LEVEL OF VITAMIN E AS A RISK FACTOR OF INCREASING SERUM BILIRUBIN IN NEONATES. Masters thesis, UNIVERSITAS DIPONEGORO.

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Abstract

ABSTRACT Background. Hyperbilirubinemia was found in 25-50% newborn babies and cause a low quality of life. Physiologically hyperbilirubinemia peak level 5-6 mg/dL on 3rd-4th days, mostly caused by hemolysis (75%) which might be due to oxidant exposure. Vitamin E protects erythrocyte membrane from oxidative damage. Objective. To analyze low levels of serum vitamin E with concern to vitamin C as a risk factor of increasing pathological serum bilirubin level in neonates. Method. A nested case control design was done in 80 healthy newborn babies in Dr. Kariadi Hospital (March-May 2009). Serum bilirubin were measured on the 3rd-4th day, serum vitamin E and vitamin C level were examined from blood sample taken on the 1st day of life. Risk factor was analyzed by odds ratio (95%CI) and logistic regression. Results. Subjects consist of 40 neonates with bilirubin ≥ 5 mg/dL and 40 with < 5 mg/dL as control group. Mean total bilirubin level (mg/dL): 9,69 (±2,41) in case and 2,81 (±1,21) in control. Mean vitamin E level (mg/dL): 0,19 (±0,03) and 0,23 (±0,02). Bivariate analysis showed that the low level of vitamin E is a risk factor to the increasing bilirubin level (OR=23,727; 95%CI 6,836-82,361). Multivariate analysis showed that the low level of serum vitamin E and vitamin C are a bigger risk factor to the increasing bilirubin level (OR=55,860; 95%CI 6,672-467,704). Conclusion. The low levels of serum vitamin E and vitamin C are a risk factor to the increasing bilirubin level in neonates. Keywords: Low vitamin E, risk factor, serum bilirubin, neonates. xix ABSTRAK Latar belakang. Hiperbilirubinemia terjadi pada 25-50% bayi baru lahir (BBL) yang dapat menurunkan kualitas hidup. Secara fisiologis bilirubin meningkat mencapai puncak pada kadar 5-6 mg/dL pada hari ke 3-4, terbanyak karena hemolisis (75%) yang kemungkinan terjadi akibat paparan oksidan. Vitamin E melindungi membran eritrosit dari kerusakan oksidatif. Tujuan. Menganalisis kadar vitamin E dengan memperhitungkan kadar vitamin C serum yang rendah sebagai faktor risiko peningkatan kadar bilirubin serum yang patologis pada neonatus. Metode penelitian. Desain penelitian adalah nested case control dengan subyek 80 neonatus aterm sehat di RSUP Dr. Kariadi pada Maret-Mei 2009, 40 neonatus sebagai kasus dan 40 neonatus sebagai kontrol. Kadar bilirubin diperiksa hari ke 3-4, kadar vitamin E dan vitamin C diperiksa dari sampel darah hari ke-1. Faktor risiko dianalisis dengan rasio odds (95% interval kepercayaan) dan regresi logistik. Hasil. Subjek 40 neonatus aterm sehat dengan kadar bilirubin ≥ 5 mg/dL sebagai kasus dan 40 neonatus dengan kadar bilirubin < 5 mg/dL sebagai kontrol. Rerata bilirubin total (mg/dL): 9,69 ± 2,41 (kasus), 2,81 ± 1,21 (kontrol). Rerata kadar vitamin E (mg/dL): 0,19 ± 0,03 (kasus) dan 0,23 ± 0,02 (kontrol). Analisis bivariat menunjukan kadar vitamin E rendah merupakan faktor risiko terjadinya peningkatan kadar bilirubin (OR=23,727; 95%CI 6,836-82,361). Analisis multivariat menunjukkan kadar vitamin E dan vitamin C rendah mempunyai faktor risiko yang lebih tinggi terhadap peningkatan kadar bilirubin (OR=55,860; 95%CI 6,672-467,704). Simpulan. Kadar vitamin E dan vitamin C rendah merupakan faktor risiko peningkatan kadar bilirubin pada neonatus. Kata kunci: Vitamin E rendah, faktor risiko, bilirubin serum, neonatus.

Item Type:Thesis (Masters)
Subjects:R Medicine > R Medicine (General)
Divisions:Postgraduate Program > Master Program in Biomedical Science
ID Code:24029
Deposited By:Mr UPT Perpus 2
Deposited On:18 Nov 2010 08:12
Last Modified:18 Nov 2010 08:12

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