PENGARUH PEMBERIAN JUS BUAH PARE (Momordica charantia) TERHADAP KADAR HDL DAN LDL KOLESTEROL SERUM TIKUS JANTAN GALUR WISTAR YANG DIBERI DIET TINGGI LEMAK

Abstract

Background: Bitter Melon or Momordica charantia, one of Indonesian natural resources which have a lot of benefit for human life. It is used as herbal medicine. One of the benefit is the effect as an antihyperlipidemic agent. Momordica charantia contains active ingredients which predict can lowering cholesterol consentration in blood, so it can prevent hyperlipidemic condition. Therefore the experiment hold to know the effect of orally administered Momordica charantia juice on HDL cholesterol and LDL cholesterol serum level in Wistar rats given high fat diet. Method: A series of experiment using control group with Pre and Post Controlled Group Design was carried out to Wistar rats given high fat diet. Sampel consists of twenty eight male Wistar rats were divided into 4 groups, they were 1 control group, received standard meal and 3 treatment groups, received additional orally Momordica charantia juice with 2 ml/day, 4 ml/day dan 6 ml/day dosages for 15 days. HDL cholesterol and LDL cholesterol analized using enzimatic method. Obtained data analized using t paired test and Anova significant degree at the 5% Result: Momordica charantia juice given to the treatment group hampered the lowering of HDL cholesterol level and hampered the rising of LDL cholesterol level which is significant (p=0.000) in all dosages compared with the control group. Optimal dosage obtained in 6 ml/day dosage because it could hampered the lowering of HDL cholesterol serum level on control group, 1st and 2nd treatment group, it was also rising the HDL cholesterol serum level exceeded the beginning level on the 3rd treatment group. Six ml/day dosage can also hampered the rising of LDL cholesterol serum level approaching the beginning level on the 3rd treatment group. Conclusion: The orally administered Momordica charantia juice in 6ml/day for 15 days could hampered the lowering of HDL cholesterol level and hampered the rising of LDL cholesterol level Wistar rats given high fat diet. Keyword: Hyperlipidemic, HDL Cholesterol, LDL Cholesterol, Momordica charantia juice