PENGARUH PEMBERIAN EKSTRAK DAUN JATI BELANDA DOSIS BERTINGKAT TERHADAP HEPAR TIKUS WISTAR

Abstract

Background: Bastard cedar is one of many plants that has medicinal effects and still used by Indonesian society as a traditional medicine. The leaf is used as slimming herbs. Because the metabolism of drug is mainly take place in the liver, thus the chance of this organ getting damage is very high. The objective of this study was to know the effects of bastard cedar leaf extract on liver of Wistar rat. Method: Experimental study with post test only controled group design. The samples were 25 Wistar rat, divided randomly into 5 groups. K group was control, only given aquades. P1 group given bastard cedar leaf extract per oral with sonde 20 mg/kgBW, P2 group given 200 mg/kgBW, P3 group given 200 mg/kgBW, and P4 group given 6324,14 mg/kgBW. Bastard cedar leaf extract was given in the first day, then observed in 7 days, and terminated in the 8th day. Result: The highest liver histopathological score was in P4 group. The score evaluate parenchymatous degeneration, hydropic degeneration, and necrosis. The ANOVA test showed significant difference (p=0,000). The Post Hoc test showed significant difference in K-P3(p=0,000), K-P4(p=0,000), P1-P3(p=0,000), P1-P4(p=0,000), P2-P3(p=0,001), and P2-P4(p=0,000). The ANOVA test of liver volume showed no significant difference(p=0,072). The ANOVA test of liver weight showed significant difference(p=0,041), continued with Post Hoc test, showed significant difference between K-P4(p=0,034). Conclusion: Bastard cedar leaf extract causes changes on liver histopathological appearance of Wistar rat as parenchymatous degeneration, hydropic degeneration, and necrosis according to dose, but did not affect volume and weight of the liver. Keywords: Bastard cedar, liver