PENGARUH PEMBERIAN GLISIN TERHADAP NILAI MCHC(Mean Corpuscular Hemoglobin Concentration) REMAJA PUTRI DENGAN ANEMIA YANG MENDAPAT SUPLEMENTASI ZAT BESI

Abstract

Background : Iron deficiency anemia is a common nutritional problem world-wide, particularly for adolescent girls in developing countries. The causes of iron deficiency are inadequate iron intake, menstrual blood loss and increased iron needs related to rapid growth. Gyicine, one of the components of hemoglobin synthesis, is predicted to enhance iron absorption, so that it may increase the MCHC value. Objectives: In order to prove the effect of Gycine on MCHC value of anemic adolescent girls that receive ferrous supplement. Method : A true experimental study using Randomized Controlled Trial. 17 adolescent girls (age 12-18 years) with light-moderate anemic (Hb=8-11,9 mg/dl), were randomized and divided into two groups, control group (receive ferrous sulfat + placebo) and treatment group (receive ferrous sulfat +glycine). The first value of MCHC were measured in both groups. After 5 weeks supplementation, the value of MCHC were measured again. Result : This research showed that after 5 weeks supplementation, MCHC value of treatment group had decreased insignificantly (p=0,171) and in control group, MCHC value had also decreased insignificantly (p=0,441). After being analized by independent sample T-test, there was no significant differences (p=0,261) between treatment group and control group. Conclusion : Glycine supplementation is not proven to raise MCHC value of anemic adolescent girls who get ferrous supplementation. Keywords : Glycine, adolescent girls, ferrous supplementation,MCHC.