PENGARUH PEMBERIAN TOLAK ANGIN ANAK CAIR TERHADAP INDEKS FAGOSITOSIS MAKROFAG PADA MENCIT SWISS

Sutejo, Willy (2010) PENGARUH PEMBERIAN TOLAK ANGIN ANAK CAIR TERHADAP INDEKS FAGOSITOSIS MAKROFAG PADA MENCIT SWISS. Undergraduate thesis, Faculty of Medicine.

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Abstract

Background: Mononuclear cell macrophage plays an important role as phagocyte and antigen-presenting cell (APC) for a specific immune system initiation that can be improved by the treatment of immunomodulator. Tolak Angin Anak Cair (TAAC), usually targeted for children, is a standardized herbal drug developed from Tolak Angin Cair (TAC) with an addition of buffalo-horn extract as antipyretic. TAC has been proven to improve peripheral T cell and Interferon-gama (IFN-γ) as the activator of macrophage. This study was designed to observe how the macrophage’s phagocytosis index on Swiss mice can be affected by an increasing dosage of TAAC. Method: Pure experimental study laboratory with Post Test Only Control Group Design was performed. Forty Swiss mice weighing 25-35 grams of 12-week old were equally divided into four groups: K (no TAAC administration), P1 (TAAC 0.125ml/day), P2 (TAAC 0.25ml/day), and P3 (TAAC 0.5ml/day). Interventions were given for seven days. Macrophages were isolated directly from peritoneal’s macrophages of mice. The data were then analyzed by Kruskal-Wallis and Mann Whitney tests. Result: Groups treated with TAAC showed a significant increased of macrophage’s phagocytosis index compared to control group (p=0.004). The treatment of TAAC that gave significant result was P2 group (0.25ml/day). Comparison between the treatment groups did not show any significant difference, except between P2 and P3 groups. Conclusion: Administration of TAAC has been proven to show a significant increased effect on macrophage’s phagocytosis index. However, the macrophage’s phagocytosis index was not directly proportional to the increasing treatment of TAAC; the optimum dosage was reached at 0.25ml/day. Key word: macrophages’s phagocytosis, immunomodulator, Tolak Angin Anak Cair

Item Type:Thesis (Undergraduate)
Subjects:R Medicine > RS Pharmacy and materia medica
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:23820
Deposited By:Ms Lutfiatun Heni
Deposited On:09 Nov 2010 09:14
Last Modified:09 Nov 2010 09:14

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