PENGARUH PEMBERIAN PRAVASTATIN TERHADAP FUNGSI MEMORI JANGKA PENDEK TIKUS WISTAR HIPERLIPIDEMIA

Abstract

Background: Pravastatin is an antihyperlipidemic drug that commonly used because relatively safe in precise dosage and usage. But it was reported in some cases that administration of pravastatin could affect short term memory. This study is aimed to prove effect of pravastatin on short term memory in hyperlipidemic wistar rats. Methods: This was a pre-post test controlled group design, using 27 hyperlipidemic wistar rats in 3 groups which 9 rats in each groups. One group is a control group, the other one was given by pravastatin 20 mg and the last one was given by pravastatin 80 mg. Three groups were given intermittent diet of egg yolk for three weeks. After that, in six weeks time control group were given aquades and treatment group each got pravastatin 20mg and pravastatin 80mg. Measurement of memory function were done four times, first were after the intermittent diet of yolk and the rest were taken in the six weeks time when treatment were given. Data were described in table, tested in Wilcoxon and Kruskal Wallis in SPSS for Windows 16.00. Result: Wilcoxon for pravastatin 80 mg between first phase and second phase, between first phase and third phase and between first phase and fourth phase were p<0,05. Wilcoxon for pravastatin 20 mg between first phase and second phase, between first phase and thid phase and between first phase and fourth phase were p<0,05. Whereas in Kruskal Wallis test were p>0,05 in first phase, second phase, third phase and fourth phase. Conclusion: Pravastatin administration hadn’t an effect on short term memory in hyperlipidemic wistar rats after 6 weeks of treatment. Keywords: Pravastatin, short term memory