PERBEDAAN KADAR HEMOGLOBIN PASIEN MULTIPEL MIELOMA PADA BERBAGAI TAHAP PEMBERIAN KEMOTERAPI ( Studi Observasional di RSUP Dr. Kariadi Semarang )

Abstract

Background: Chemotherapy of patiens with multiple myeloma cause changes hemoglobin concentration that an indication of changes in nutritional status. Changing of hemoglobin concentration is influenced by multiple myeloma stage, gender, and age of the patient. This study aims to determine the hemoglobin differences between before and after the first to six chemotherapy. Method: The study used medical records of 68 patients with multiple myeloma who seek treatment at Dr Kariadi. Data were analyzed using Paired Samples T test to determine differences of hemoglobin concentration between pre-and post-chemotherapy, uji Kruskal Wallis untuk mengetahui perbedaan perubahan kadar hemoglobin sebelum dan setelah kemoterapi pada berbagai stadium (1, 2 ,dan 3), uji Mann-whitney untuk mengetahui perbedaan perubahan kadar hemoglobin pada laki-laki dengan perempuan, dan uji korelasi spearman untuk mengetahui hubungan antara umur pasien. Results: There were significant differences in hemoglobin level before chemotherapy with chemotherapy after the first, second, third, fourth, fifth and sixth (p = 0.00, 0.00, 0.00, 0.04, 0.014, and 0, 2002).There were no significant differences in hemoglobin concentration changes before and after chemotherapy at various developmental stages (p = 0.934), and gender (p = 0.41) There was no correlation between changing of hemoglobin oncentration with patient age (p = 0.087). Conclusion: There are differences in hemoglobin concentration among patients with multiple myeloma before chemotherapy and after chemotherapy I, II, III, IV, V, and VI. There were no differences in hemoglobin concentration changes at different stages and genders. Tedapat no relationship between age and change in hemoglobin concentration in Dr Kariadi semarang. Keywords: hemoglobin concentration, chemotherapy, multiple myeloma Stadium, age of the patient.