PENGARUH PEMBERIAN EKSTRAK KULIT BUAH DELIMA PUTIH (Punica granatum Linn) DAN KETOKONAZOL 2% TERHADAP PERTUMBUHAN Candida albicans SECARA IN VITRO PADA KANDIDIASIS VULVOVAGINALIS

Abstract

Background : Vulvovaginal candidiasis is a common fungal infection that mainly caused by Candida albicans. Pomegranate (Punica granatum Linn) Rind has an antifungal activity because of its tannin contain. This study aimed to compare the effectiveness of pomegranate (Punica granatum Linn) rind extract and ketoconazole 2% against the in vitro growth of Candida albicans in vulvovaginal candidiasis. Method : This was a laboratory experimental study whose samples were taken from vaginal swab of vulvovaginal candidiasis patients in Sunan Kuning, Semarang. Thirty samples with positive colony of Candida albicans were each cultivated in two media: Ketoconazole 2% contained Sabouraud Dextrose Agar (SDA) and 100% Pomegranate Rind Extract (PRE) contained SDA which are incubated in 37°C for 24-48 hours. The data is obtained by observing the growth of Candida albicans colonies in both media. Result : All 30 media of SDA which contained 100% PRE were found Candida albicans (-). The data wasn’t eligible for chi-square test thus Kolmogorov-Smirnov test was used and the result was p=1.00 (not significant). Conclusion : 100% PRE has effectiveness that is not significantly different with 2% ketoconazole in inhibiting the in vitro growth of Candida albicans in vulvovaginal candidiasis. Key words : Vulvovaginal candidiasis, Candida albicans, pomegranate rind extract, 2% ketoconazole