PENGARUH PEMBERIAN EKSTRAK BAWANG MERAH ( Allium ascalonicum) TERHADAP KADAR KOLESTEROL HDL SERUM TIKUS WISTAR HIPERLIPIDEMIA

Abstract

Background: Shallot (Allium ascalonicum) extracts contains phytochemistry compound such as quercetin and allicin. Many literature said that both compound could increase HDL cholesterol level by increasing apo A1 production. The aim of this research is to find out the effect of shallot extracts to increase HDL cholesterol serum level compare to the control group. Methods: The design of this experimental study was randomized post-test only control group design. The samples were twenty eight male Wistar divided into 4 groups, K-, K+, P1, and P2. Group K- treated with standard diet. The other three groups were injected by 0,006 mg adrenalin i.v on the first day followed by egg yolk dietary on 2nd-28th. After that group K+ was given standard diets, group P1 was given 750 mg/1 ml of shallot extract, group P2 was given 1500 mg/ 2 ml of shallot extracts for 3 weeks. The data were analized with Kruskal-Wallis and Mann-Whitney test after normalized data with Saphiro Wilk test. Result: HDL Cholesterol level of treatment group K+ (21) is lower than goup K- (22). Group P1 (18) is lower than group K+. Group P2 (20) is higher than group P1 but lower than group K+. Kruskal Wallis test between control group and treatment group was not significantly different (p=0,2, p>0,05). In Mann-Whitney test between group K+ and P1 was significantly different (p=0,013,p<0,05) but in other group, Mann-Whitney test was not significantly different. Conclusion: The various doses of shallot extracts dietary, 750 mg/1 ml and 1500 mg/2 ml, had no significantly difference between control group and treatment group. Keywords: shallot extracts, HDL cholesterol serum, hyperlipidemia