PENGARUH LAMA PEMBERIAN MOMORDICA CHARANTIA L. TERHADAP JUMLAH SPERMATOZOA PADA TIKUS BALB/C DEWASA JANTAN

Abstract

Background : Momordica charantia L.fruit is known that can reduce the concentration of spermatozoa, that is because Momordica charantia L.fruit contents with glikosida triterpen. Glikosida triterpen can reduce the motility or movement, the endurance and consentration of sperm, and also can cause abnormality to the accessories glands in reproduction organ. Glikosida triterpen in Momordica charantia L. can also obstruct the spermatogenesis process. But, the antifertility from glikosida triterpen is not permanent or it is reversibel. The aim of this study is to know how long the effect of Momordica charantia L.. dietary to decrease the concentration of spermatozoa male Balb/c rats. Method : Experimental study with post test only control group design was conducted in Parasitology laboratory of Faculty Medicine of Diponegoro University, Semarang. The Momordica charantia L. extract is made with maserasi metode in Chemistry laboratory of Faculty Medicine of Diponegoro University, Semarang. Forty eight Bab/c rats were divided into four groups. Control group is treated with standard diet, Group I was treated with dosage of 900 mg/kgBB/hari for 20 days, Group II was treated with dosage of 900 mg/kgBB/hari for 40 days, Group III was treated with dosage of 900 mg/kgBB/hari for 60 days. All rats used in the experiment were adapted with standard diet for 7 days, and treatments were given for 60 days towards. At day 20 the rats from Group I were terminated for counting the concentration of spermatozoa. At day 40 the rats from Group II were terminated for counting the concentration of spermatozoa. And At day 60 the rats from Group III and Control Group were terminated for counting the concentration of spermatozoa. Data were analyzed with SPSS .15.0 for windows. Result : The result of research revealed that mean concentration of spermatozoa (in million) of 4 group are : Control Group : 13,40; Group I : 10,57; Group II : 4,67; and Group III : 5.75 Conclusion : The result showed that all Momordica charantia L.diet were able to decrease the consentration of spermatozoa. During the 20 days of Momordica charantia L.diet the concentration of spermatozoa is reduce. During the 40 days of Momordica charantia L. diet the concentration og spermatozoa is more reduce than before. But, during the 60 days of Momordica charantia L. diet the consentration of spermatozoa is not reduce than before. Key Word : Momordica charantia L., concentration of spermatozoa.