PERBEDAAN GAMBARAN HISTOPATOLOGI BRONKUS ANTARA INJEKSI HCL DAN CAIRAN LAMBUNG INTRATRACHEAL PADA MODEL SINDROM ASPIRASI PARU TIKUS WISTAR

Abstract

Background: Pulmonary aspiration is one of the acute lung injuries which is caused by gastric fluids. The characteristic of gastric fluids is acid. This acid can irritate to the bronchus. The research about pulmonary aspiration by gastric fluids and HCl to bronchus histopathology remains seldom to be done so this research’s aim is to prove, that there is differences of bronchus histopathology appearance between HCl and gastric fluids aspiration using model of pulmonary aspiration syndrome. Methods: This research was an experimental studywith test only controled group design. Samples were 25 male wistar rats, 10-12 weeks, divided into five groups. Control group were given injection of a normal saline 0,4 ml/KgBB intratracheal, P1 and P2 were given HCl injection 0,4 and 1 ml/KgBB intratracheal, P3 and P4 were given gastric fluids injection 0,4 and 1 ml/KgBB intratracheal. The Data was taken from the examination of the bronchus histophatology of wistar rats. Data was analyzed with test of ANOVA and test Post Hoc. Result: Average score of mucosal epithelium bronchus damage significantly difference among five groups (p=0,001). Average score of mucosal epithelium bronchus damage of group K was the smallest (2,1±0,83). While, the biggest average score of mucosal epithelium bronchus damage was P4 (12,8±0,88). There was a significant of difference among group K-P1 (0,001), K-P2 (0,001), K-P3(0,001), K-P4(0,001), P1-P2(0,038), P1-P3(0,015) and P1-P4(0,001) Conclusion: Gastric fluids cause significantly more damage of bronchus histopathology than HCl. Increasing of volume HCl can more damage of bronchus histopathology but there is no difference in the bronchus hitopathology of gastric fluids volume increase on the model of pulmonary aspiration syndrome. Keywords: histopathology bronchus appearance, HCl, gastric fluids