PENGARUH INJEKSI HCG TERHADAP KADAR TESTOSTERONE PADA PENDERITA SEX CHROMOSOME DSD DENGAN VARIASI KARIOTIP

Abstract

Background: Sex chromosomal DSD is condition that occurs due to sex chromosome abnormality, both in quantity or structural abnormalitie. This research was conducted to know the effect of hCG injection (hCG test) to increasing of testosterone levels in patients with varied karyotype sex chromosomal. HCG test done to confirm the existence of testicular tissue and to measure testicular function to produce testosterone. Methods: This is an experimental study with one group pretest post test design, by comparing the results of observation in the treatment group before and after hCG injection (hCG test), to know the effect of hCG injection to testosterone levels in patients with varied karyotype sex Chromosomal DSD that recorded in Center for Biomedical Research (CEBIOR) Faculty of Medicine Diponegoro University, Semarang. The number of research subjects is 19 patients. Results: hCG test results showed a significant increase in testosterone levels after hCG test, with significancy value of 0.000 (p <0.005). Most patients (73.33%) gave a good response to the hCG test. There are large variations in the response of patients with sex chromosomal DSD to hCG test, even in patients who are classified at the same syndrome. Conclusion: Most patients with sex chromosomal DSD who examined in CEBIOR showed a significant rise in testosterone levels after hCG test. This confirms the existence of testicular tissue and testicular function is good in most patients. However, hCG test results should be complemented with the results of other investigations, for example, physical examination, internal and external genitalia in particular, to obtain a more accurate conclusion. Keywords: Sex chromosomal DSD, hCG test