Efek Meniran (Phyllanthus niruri Linn)terhadap Kadar AST dan ALT Mencit Balb/C yang Diinduksi Asetaminofen

Abstract

Background: Stone breaker (Phyllanthus niruri) has a potency as hepatoprotector because it contains phyllanthin and hypophyllanthin. This substances have ability as antioxidant agent, increasing hepatocyt viability, decreasing lipid peroxyde, anda increasing glutathion. This study goal is to learn is there any AST and ALT changes between mouse that induced by Phyllanthus niruri and not after acetaminophen induced toxicity. Methods: This study design was randomized postest control group design using Balb/C mice as sample. Twenty four mouse that fulfilled inclution and exclution criteria were randomized and classified became 4 groups equally, that were control group, group that induced by acetaminophen only, group that induced by acetaminophen and 0,39 mg dose Phyllanthus niruri, and group that induced by acetaminophen and 3,9 mg dose Phyllanthus niruri. Phyllanthus niruri extract administered oraly for 7 days. After treatment, mice blood was taken to measure AST and ALT level. The data were described in table and picture form. Statistic test used Kruskal-Wallis test. Result: From Kruskal-Wallis test,AST p score was 0,168 and ALT p score was 0,726. Both of them showed that there was no AST and ALT level change between 4 mouse group. Conclusion: There was no AST and ALT difference between Balb/C mouse induced by Phyllanthus niruri and Balb/C mouse that not induced by Phyllanthus niruri after acetaminophen induction. Keyword: Phyllanthus niruri, acetaminophen, AST, ALT