PENGARUH PEMBERIAN MENIRAN (Phyllanthus niruri Linn) TERHADAP GAMBARAN HISTOPATOLOGIS HEPAR MENCIT BALB/C YANG DIINDUKSI ASETAMINOFEN

Abstract

Background: Liver is one of the most important organ in the body. Thus, liver become more vulnerable toward damages from outside. So liver needs substance which can prevent or protect it from those damages. This study is aimed to prove the effects of stone breaker on Balb/C liver histopathologic feature induced by acetaminophen. Methods: This study was post test only control group design by using Balb/C mice. About 24 mice which has fullfilled inculsion and exclusion criterias acclimated during a week and was divided into 4 groups. Those groups were mice control group, acetaminophen-only mice group, mice which was given acetaminophen and 0,39 mg/kgBB dose of stone breaker group, and mice which was given acetaminophen and 3,9 mg/kgBB dose of stone breaker group. The acetaminophen was given to the mice only in day 2 while the stone breaker was given to the mice a week after acetaminophen. Then their livers will be taken and read for microscopic examination. And then it would be analyzed by using SPSS 17.00 for Windows with Kruskall-Wallis method. Result: In Kruskall-Wallis method, it was meaningful difference between the groups with p=0.011. Although in post hoc test between treated groups those meaningful difference wasn’t found between P1 and P2 groups with p=0.806. Conclusion: There is effect of stone breaker on Balb/C mice histopathologic feature induced by acetaminophen. Keywords: stone breaker, liver histopathologic feature, acetaminophen