PERBEDAAN HISTOPATOLOGIS ALVEOLUS ANTARA INJEKSI HCL DENGAN CAIRAN LAMBUNG INTRATRACHEAL PADA MODEL SINDROM ASPIRASI PARU TIKUS WISTAR

Aulia, Khilyatul (2010) PERBEDAAN HISTOPATOLOGIS ALVEOLUS ANTARA INJEKSI HCL DENGAN CAIRAN LAMBUNG INTRATRACHEAL PADA MODEL SINDROM ASPIRASI PARU TIKUS WISTAR. Undergraduate thesis, Faculty of Medicine.

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Abstract

Background : Aspiration is a risk of anesthetic induction that be happened on intubation periode, post intubation, and post surgery. Even its mortality rate was low, improper management will increase the morbidity rate. Objective : The objective of the study is to prove the difference of alveolus histopathology between HCl and gastric fluids intratracheal injection in wistar rats model of pulmonary aspiration syndrome. Methods : This research design use post test only control group design on 25 wistar male rats divided into 5 group. K group was control which was given normal saline 0,4ml/KgBW, P1 group given with HCl 0,4ml/KgBW, P2 group was given HCl 1ml/KgBW, P3 group was given gastric fluids 0,4ml/KgBW, and P4 group was given gastric fluids 1ml/KgBW. All the fluid were injected intratracheal. After 15minutes, all rats were anesthetized with ether followed by termination and examination microscopically Result : The highes score of what was in P4. The score is evaluated base on degeneration of alveolus wall. The normality test use Saphiro-Wilk then continued with Oneway ANOVA. The Oneway ANOVA showed unsignificance defferences(P=0,138). Conclusion : HCl injection with gastric fluids intratracheal in defferences doses for about 15minutes in wistar rats model of pulmonary aspiration syndrome coused changes alveolus histological feature as mild oedema. Keywords : Pulmonary aspiration syndrome, Alveolus histological feature

Item Type:Thesis (Undergraduate)
Subjects:R Medicine > RD Surgery
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:23404
Deposited By:Ms Lutfiatun Heni
Deposited On:21 Oct 2010 12:19
Last Modified:21 Oct 2010 12:19

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