PERBEDAAN RESPON KARDIOVASKULER ANTARA FENTANIL 2g/kg DAN KLONIDIN 3g/kg PADA TINDAKAN LARINGOSKOPI DAN INTUBASI

Abstract

Background : Laryngoscopy and intubation often cause increased blood pressure and heart rate. Administration of fentanyl and clonidine is one way that can be used to reduce the cardiovascular response. This study aimed to prove the differences between the administration of fentanyl 2μg/kg and clonidine 3μg/kg intravenously in reducing cardiovascular response due to laryngoscopy and intubation. Method : A retrospective observational study with cross sectional design. Data derived from secondary data with a sample of 48 patients. Patients who meet inclusion and exclusion criteria were divided into 2 groups. In the group 1 given fentanyl 2μg/kg intravenously and group 2 given clonidine 3μg/kg intravenously. Systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate were recorded in the 1st, 3rd, and 5th minutes after intubation. Data analysis using SPSS 15 for Windows. Result : In the 1st, 3rd, and 5th minutes after intubation showed significant differences in systolic blood pressure (p <0.05) between both groups. On diastolic blood pressure and mean arterial pressure the significant difference was found only in the 3rd minute (p <0.05), whereas in heart rate showed no significant difference (p> 0.05). Conclusion : There is a difference between administration of fentanyl 2μg/kg and clonidine 3μg/kg intravenously in supressing blood pressure. Clonodine 3μg/kg was found to be more better in supressing blood pressure compared to fentanyl 2μg/kg. There is no difference between administration of fentanyl 2μg/kg and clonidine 3μg/kg intravenous in supressing heart rate. Keywords : cardiovascular response, fentanyl, clonidine, laryngoscopy intubation