PENGARUH PEMBERIAN TEH HITAM (CAMELIA SINENSIS) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR MENCIT BALB/C

Abstract

Background : Tea is a beverage ingredients that are universally consumed in many countries and in different layers community. Black tea is known to contain various compounds such as theaflavins. The liver functions as detoxification of toxic substances from excretion is an important tool other than kidney. This study aimed to observe the effect of black tea (Camelia sinensis) administration on liver histophatology of Balb/c mice. Method : This research is an experimental design with the post test only control group design in Balb/c mice which consists of 15 male mice, divided into three groups. P is the treatment group is P1 giving black tea extracts were given 25.4 mg/cc/day, P2 giving black tea extracts were given 50.8 mg/cc day, and P3 giving of black tea extracts given 101.6 mg/cc/days. After getting treated for 30 days, the mice were terminated and then done taking liver tissue for histological preparations made. Result : Examination of liver histopathology of Balb/c mice indicates the average degree of damage in each group is P1 = 2.284, P2 = 1.918, and P3 = 1.364. Conclusion : Giving of black tea (Camelia sinensis), which were given orally for 30 days until the dose of 101.6 mg/cc indicates the degree of damage to liver histopathology Balb/c lower with increasing doses of giving black tea extract. Keywords : histopathology of liver, black tea