EFEKTIVITAS EKSTRAK SELEDRI(APIUM GRAVEOLENS) 50% DIBANDINGKAN KETOKONAZOL 2% TERHADAP PERTUMBUHAN MALASSEZIA SP. PADA KETOMBE

Abstract

Background: Pityrosporum ovale, a lipophilic yeast of the genus Malasezzia that is a common comensal of the scalp, increases in dandruff. The use of ketoconazole as an active ingredient in antidandruff is based on the role of Malassezia sp. as causal microorganism. Traditional treatment to eliminate dandruff can be found in the population too. The celery extract can be used to eliminate dandruff. In this case the antimicrobial or antifungal effects of this plant are suspected as having important role. This study aims to examine the comparative effectiveness of the 50% celery extract (Apium graveolens) with 2% ketoconazole in vitro on the growth of Malassezia sp. in dandruff. Method: This research was done by using an experimental study. The samples were 30 (+) Malassezia sp. inoculated in SDA . The result of the culture (+) are diluted in sterile solution of 0.9% NaCl and its turbidity is made equal with 0.5 McFarland solution, then 0.1 cc was taken and cultivated in medium of SDA olive oil that contained 50% celery extract and medium of SDA olive oil that contained 2% ketoconazole. Then the medium was entered in an incubator at temperature of 370C for 3 days. The data were analyzed using chi square test with degree of significance of p<0,05. Result: 30 media of olive oil SDA that contained 50% celery extract, 3 were stated as (+) that revealed growth of Malassezia sp. and 27 was stated as (-) that revealed no growth of Malassezia sp.. Whereas from 30 media of SDA olive oil that contained 2% ketoconazole, 2 were stated as (+) that revealed growth of Malassezia sp. and 28 were stated as (-) that revealed no growth of Malassezia sp. The fisher test is not significant, p=1,00 (p>0,05). Conclusion: 50% Celery extract has same effective in compared with ketoconazole 2% in retarding the growth of Malassezia sp. in dandruff. Key words : Celery extract, 2% ketoconazole, Malassezia sp., dandruff.