PENGARUH FAKTOR DEMOGRAFI TERHADAP KEJADIAN INFEKSI DAN POLA RESISTENSI Staphylococcus aureus Pasien di RSUP Dr Kariadi SemarangPeriode 2008-2009

Abstract

Background: Staphylococcus aureus is one of the most common microorganisms causing infections in hospitals. The increasing incidence of infectious disease and the occurrence of resistance of S. aureus against various antibiotics requires a broader understanding of the factors that can influence it. This study aimed to analyze the influence of demographic factors on the incidence of infection and resistance patterns of S. aureus in patients of Dr. Kariadi hospital in Semarang between the period of 2008 to 2009. Methods: This research was a cross-sectional study, data collected from medical records and laboratory work. The information from a number of clinical material samples from hospitalized patients in Dr. Kariadi hospital between the period of 2008 to 2009 were searched from medical records. Clinical material fulfilled the criterias for inclusion and exclusion were cultured on solid medium blood agar. After overnight incubation, pure colonies were identified by gram staining, catalase test and coagulase test. Antimicrobial susceptibility testing of S. aureus was performed by disk diffusion method on Mueller-Hinton agar. Result: Culture was performed on 100 clinical materials. Results of bivariate and multivariate analysis indicates no significant influence. Age (p=0,094; RP=0,723, CI 95% 0,45-1,14), gender (p=0,476; RP= 1,083, CI 95% 0,87-1,35), and residence (p=0,338; RP=0,898, CI 95% 0,72-1,12) did not influence the incidence of S. aureus infection. In addition, age (p=1,000; RP=1,000, CI 95% 0,48-2,48), gender (p=1,000; RP=1,000, CI 95% 0,64-1,57), and residence (p=0,251; RP=1,304, CI 95% 0,82-2,07) did not influence the incidence of Multidrug resistance S. aureus. Conclusions: Demographic factors did not influence S. aureus infection and antimicrobial resistance in hospitalized patients in Dr. Kariadi hospital in Semarang between the period of 2008 to 2009. Keywords: Staphylococcus aureus, demographic factor, resistance pattern