EFEKTIFITAS EKSTRAK JAHE (ZINGIBER OFFICINALE ROSC.) 3,13% DIBANDINGKAN KETOKONAZOL 2% TERHADAP PERTUMBUHAN MALASSEZIA SP. PADA KETOMBE

Abstract

Background: The rhizome of ginger (Zingeber officinale Rosc.) containing gingerols, gingerdiols, and zingerone which is antifungal. Ketoconazole 2%, which inhibit the synthesis of ergosterol to maintain the integrity of the fungi’s walls are used for medical therapy for people with dandruff. This study aimed to examine the effectiveness of ginger extract in compared with 2% ketoconazole against the growth of Malassezia sp. on dandruff. Methods: The design of this research is experimental research with a post test only control group design, with samples cultured SDA (+) Malassezia sp. were taken from 30 patients with dandruff who satisfy the inclusion and exclusion criteria, held in April until May. Samples. The effectiveness of ginger extract and effectiveness of 2% ketoconazole that seen with the growth of Malassezia sp. on SDA culture as the independent variable, and the growth of Malassezia in the media SDA as the dependent variable. Data were analyzed using Fisher's test with significance level p0,05. Results: Thirty SDA which contained 3,13% extract of ginger, were found 7 Malassezia growth positive (+) and 23 Malassezia growth negative (-). Thirty SDA which contained 2% ketoconazole, 2 were found Malassezia growth (+) and 28 Malassezia growth (-). The result of fischer exact test is not significant (p=0,145) Conclusion: No significant difference between the effectiveness of 3,13 ginger rhizome extract compared with 2% ketoconazole in inhibiting the growth of Malassezia sp. on dandruff. Keywords: Dandruff, Malassezia sp., ginger (Zingeber officinale Rosc.) extract, 2% ketokonazole.