PENGARUH PEMBERIAN EKSTRAK VALERIAN TERHADAP GAMBARAN MIKROSKOPIS HEPAR DAN DUCTUS BILIARIS TIKUS WISTAR

Abstract

Background: Valerian (Valeriana officinalis) has been used for a long time as traditional medicine but its side effect haven’t been known much. Liver is the main metabolism organ and biliary duct is the organ that transport bile that contains metabolite and drugs out from the liver. These functions made the two organs likely to be damaged. The objective of this research is to find out the effect of valerian extract to microscopic display of the liver and biliary duct. Method: This research was an experimental study using the post test only controlled grou design. The samples were 20 wistar rats, randomly divided into 4 groups. K was control group which was only given aquadest. P1, P2, and P3 were treatment groups Which was given valerian extract 9 mg/kgBW, 18mg/kgBw, and 36mg/kgBW. The extract were given orally by using sonde. After the third month, the wistar rats was terminted, the liver was extracted for the observation of the microscopic appearance of the liver and biliary duct. Result: The Anova test showed there were significant difference in the microscopic appearance of the liver(p=0,000). Followed with Post Hoc test that showed significant difference between the control group (K) compared to the treatment groups (P1,P2, P3) and among the treatment group. The anova test for the biliary duct showed there were no significant difference between groups (p=0,804) Conclusion: The use of valerian extract caused damage to the liver but didn’t cause damage the biliary duct Keywords: Valerian, liver microscopic, biliary duct microscopic