PENGARUH EKSTRAK ETANOL RIMPANG KUNYIT (Curcuma domestica Val) TERHADAP JUMLAH GELIATAN MENCIT BALB/C YANG DIINJEKSI ASAM ASETAT 0,1%

Abstract

Background : Turmeric (Curcuma domestica Val) is one of a traditional herbal plant which is commonly used as an analgetic. The aim of this study is to know if Turmeric (Curcuma domestica Val) has the effect to reduce the pain. Method : This experiment is an experimental study with post only control group design. Samples are used for this experiment contains of 25 Balb/c mice male, divided randomly into 5 groups.Some criteria of the mice are, they must have 15-30 gram weight and 2-3 months age. All mice are used in this experiment were adapted with standard diet for 7 days, before used all mice were fasted 8 hours. First, second, and third group are treaten group was given etanol Turmeric (Curcuma domestica Val) rhizome extract with dossage 7mg/20gramBB, 14mg/20gramBB, and 14mg/20gramBB. Fourth group is the negative control was given vehiculum. Fifth group is the positive group was given aspirin 1,3mg/20gramBB. After 15 minutes all the group are injected 1 ml Acetic Acid 0,1% intraperitoneally, then examinated and counted mice writhing. Data were analyzed with Spss 15.0 for windows Result : The result from the Post Hoc Test showed no significant differences between K(-) and P1; K(+) and P3. While there is significant differences between K(+) and K(-); K(+) and P1; K(+) and P2; K(-) and P2; K(-) and P3; P1 and P2; P1 and P3; P2 and P3. Conclusion : The result showed that the etanol turmeric rhizome extract can cause the quantity of the mice writhing which is injected acetic acid 0,1% intraperitoneally. More high dossage which is given must give more effect to reduce the pain. However Aspirin still be more effective than each gradual dossage of the etanol turmeric rhizome extract. Keyword : Extract, Curcuma domestica Val, Writhing, Aspirin.