PERBEDAAN PENGARUH PEMBERIAN PROPOFOL DAN TIOPENTAL TERHADAP RESPON HEMODINAMIK PADA INDUKSI ANESTESI UMUM

Abstract

Background: General anesthesia have a risk to cause side effects of hemodynamic response disorder. Administrations of propofol and thiopental are known to suppress hemodynamic changes induced by general anesthesia. This study aimed to prove the existence of differences in hemodynamic responses between propofol and thiopental administrations in induction of general anesthesia. Metode: The study design was a retrospective observational (cross sectional), with 48 samples of patients who underwent a surgery that meet the criteria for inclusion and exclusion in IBS Dr. Kariadi during March to May 2010. Divided into group 1: using propofol 2 mg/kg intravenously, group 2: using thiopental 4.5 mg/kg intravenously. Systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate were recorded on the 1st, 5th, and 10th minutes after induction. Data analysis using SPSS 15 for Windows. Result: Study results showed that blood pressure decreased in both groups after induction, but the reduction in thiopental group was greater than propofol. And statistically the blood pressure reduction in both groups was significantly different (p <0.05). While the mean arterial pressure and heart rate in both groups were not significantly different (p> 0.05). Conclusion: There is a difference between propofol and thiopental intravenous in reducing the hemodynamic response. Propofol was found to be more stable and causes less change in suppressing hemodynamic response compared to thiopental. Keywords: thiopental, propofol, haemodynamic, general anesthesia induction