PENGARUH PEMBERIAN EKSTRAK VALERIAN (Valeriana officinalis) TERHADAP GAMBARAN MIKROSKOPIS HEPAR DAN KADAR SGOT TIKUS WISTAR

Abstract

Background: Valerian is a medicinal plant potential for insomnia. Active substance in Valerian roots such as valepotriates, volatile essential oil, and alkaloid metabolism primarily taken place in the liver, thus the chance of this organ getting damage is very high. The objective of this study was to know the effects of Valerian extract on liver microscopic appearance and SGOT level of wistar rat. Methode: This research was an experimental study using the Pre and Post Test Only Control Group Design for SGOT level and Post Test Only Control Group Design for microscopic appearance.the samples were 20 wistar rat, randomly divided into 4 groups. K was control group which was only given aquadest. P1,P2,P3 were treatment groups which were given valerian exctract 9, 18 and 36 mg/kgBB for 3 months.At the end of 3rd month the wistar rat were terminated to observed the microscopic appearance and SGOT level. The obtained data were analyzed using Oneway-Anova test followed by Post-Hoc test. Result: The scores are assessed include changes in parenchymatouse degeneration, hydropic degeneration, and necrosis. The statistical result of microscopic liver between the control (K) and treatment (P1, P2, P3)( p<0,05). The statistical result of SGOT Pre Test (p> 0.05), Post Test (p> 0.05) and delta (p> 0.05). Conclusion: The effects of valerian exctract affect the microscopic appearance and SGOT level of wistar rat. Keywords: Valerian, liver microscopic, SGOT