PENGARUH PEMBERIAN EKSTRAK VALERIAN TERHADAP GAMBARAN MIKROSKOPIS HEPAR DAN KADAR SGPT TIKUS WISTAR

Abstract

Background: Valerian (Valeriana officinalis) is one of medicinal plant families in Indonesia. The active content of valerian, valepotriates and sesquiterpenes in the volatile oil have a hepatotoxic properties. Drug metabolism mainly occur in the liver, so that the possibility of damage to this organ becomes very large. The purpose of this study is to prove the effects of valerian on microscopic appearance and SGPT level of wistar rat. Methods: This research was an experimental study using the post test only control group design for microscopic examination of the liver and pre and post test control group design for SGPT level examination. The sample consisted of wistar rats which are divided into four groups. K was control group who were given just only water. P1, P2, P3 were treatment groups who were given valerian extract 9 mg/kgBW, 18 mg/kgBW, 36 mg/kgBW. The extract was orally given with sonde on the first day. At 120th day wistar rat were terminated , liver were taken and observed the microscopic appearance and blood sample were taken for measuring the SGPT post test level. Result: The statistical test for microscopic liver was obtained between the control (K) and treatment (P1,P2,P3) with p<0,05. The statistical test for SGPT level pre test (p>0,05), post test (p>0,05) and delta SGPT (p>0,05). Conclusion: Valerian extract give effect on the miroscopic appearance of wistar rat liver and do not give effect on SGPT level of wistar rat. Keywords: Valerian, liver microscopic, SGPT level.