Uji Toksisitas Akut Ekstrak Etanol Buah Cabai Rawit (Capsicum frutescens) Terhadap Larva Artemia salina Leach Dengan Metode Brine Shrimp Lethality Test (BST)

Widianti, Andika (2010) Uji Toksisitas Akut Ekstrak Etanol Buah Cabai Rawit (Capsicum frutescens) Terhadap Larva Artemia salina Leach Dengan Metode Brine Shrimp Lethality Test (BST). Undergraduate thesis, Faculty of Medicine.

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Abstract

Background: The use of cayenne as a traditional medicine needs to be supported by scientific information about the efficacy and side effect. The objective of this research is to prove the presence of toxicity potency in ethanol extract of cayenne using BST methods. Method: An experimental research use Post Test Only Control Group Design. Total sampel were 250 Brine shrimp (Artemia salina Leach) larvae. Ten larvae used in each 5 groups with 5 times replication. Each group was consecutively given 500, 200, 100, 50,0 µg/ml concentrate of ethanol extract of cayenne, the fifth group was used as control. Data obtained by calculating amount of died larva in 24 hours after treatment. LC50 value was analyzed by probit analysis using SPSS 16.0 for windows. Result: The average mortality of larvae at a concentration of 500, 200, 100, 50, and 0 µg/m consecutively were 10, 7.4, 4.6, 3.2, and 0. The higher the extract concentration led to a growing number of high larval mortality (y=0,714x-0.918). LC 50 value of fruit extract of cayenne was 93,389 μg/ml. Conclusion: LC50 <1000 μg / ml indicates ethanol extract of cayenne pepper fruit own a potential for acute toxicity to larvae of Artemia salina Leach. Key words:Capsicum frutescens, cayenne, brine shrimp lethality test, acute toxicity.

Item Type:Thesis (Undergraduate)
Subjects:R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:23064
Deposited By:Ms Lutfiatun Heni
Deposited On:13 Oct 2010 14:03
Last Modified:13 Oct 2010 14:03

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