FAKTOR RISIKO KEMATIAN PENDERITA SIROSIS HATI DI RSUP Dr. KARIADI SEMARANG TAHUN 2002 - 2006

Abstract

Background: Liver cirrhosis was a pathological condition when liver got damaged and its function was disturbed. In Indonesia, liver cirrhosis and its complication became a heatlh problem which was hard to overcome. This was signed with the high rate of morbidity and mortality . Objective: To know the risk factors of mortality of cirrhotic patients in dr. Kariadi Hospital Semarang. Methods: The study was observational analytic with case-control approach. The case samples were cirrhotic patients who died and control samples were the ones who survived. The data was analized by using odds ratio, chi-square, t-test and Mann-Whitney. Results: The total of cirrhotic patients in the year of 2002 until 2006 was 637 people. Mortality rate was 9,7% with the most frequent cause of death was hepatic encephalophaty (45,2%). In case group, most patients were men (61,3%), aged more than 60 years old (46,8%), frequent complications were esophageal variceal bleeding and hepatic encephalophaty, had diabetes mellitus as comorbid disease (25,6%), classified as Child-Pugh C and mean score of MELD was 19,18. In control group, most patients were men (74,2%), aged between 50 to 59 years old (35,5%), the most frequent complication was esophageal variceal bleeding, had diabetes mellitus (26,7%) and hipertension (26,7%) as the most frequent comorbid disease, classified as Child-Pugh B and mean score of MELD was 16,07. Statistically, there were significant correlation between hepatic encephalophaty, esophageal variceal bleeding, septic shock, Child-Pugh and MELD score with mortality of cirrhotic patients. Conclusions: In this study, hepatic encephalophaty, septic shock and the increase of Child-Pugh and MELD score were mortality risk factors and esophageal variceal bleeding increased mortality risk of cirrhotic patients. Keywords: risk factor, mortality, liver cirrhosis