PENGARUH PEMBERIAN ASPIRIN BERBAGAI DOSIS PER ORAL TERHADAP GAMBARAN HISTOPATOLOGI HEPAR TIKUS WISTAR

Abstract

BACKGROUND: Despite the introduction of many new drugs, aspirin (acetylsalicylic acid) is still the most widely prescribed antiinflammatory agent and is the standard for the comparison and evaluation of the others.Aspirin is the common household analgesic; yet, because the drug is so generally available, its usefulness often underrated. OBJECTIVE: The study was aimed to proving the effect of aspirin, which is given in any dosages, to liver histology pattern in mice. METHOD: This was an experimental study using the post test only control group design. Samples were 24 male wistar mice divided into four groups, K(control), were not given aspirin; group P1:were given aspirin ½ x 1106 mg; Group P2: were given aspirin 1106 mg; Group P3: were given aspirin 2 x 1106 mg. The liver was taken and processed histopatologically using HE staining.Degree of the hepatocytes destruction were counted. Data were analyzed by differentiating test Kruskal-Wallis and Mann-Whitney. RESULT: Kruskal-Wallis test among treatment groups shows mean differences (p=0,00). Continued with Mann Whitney-test between control and group I (p=0,004), control and group II (p=0,004), control and group III (p=0,004), group I and II (p=0,04), between group I and III (p=0,004), group II and III (p=0,06) CONCLUSION: There were significantly differences on liver histopathology pattern is effect for giving aspirin in any dosage per oral between groups treated with aspirin and group which didn’t receive any aspirin, with different damage level. Keywords: aspirin, hepar histopathology image