GAMBARAN HISTOPATOLOGI HEPAR TIKUS WISTAR SETELAH PEMBERIAN ASETAMINOFEN BERBAGAI DOSIS

Abstract

Background: Acetaminophen is used commonly by population as analgesic, yet many cases showed the use of this drug has over allowable dose. Lots of data showed rising of death because of liver failure, because overdoses. Biotransformation of acetaminophen happen in liver, it turns acetaminophen into substance which is not toxic. On overdose, liver cannot detoxify, and cause injury to hepatosit cell. Objective: Identify the effect of acetaminophen variance doses toward the histopathology appearance of wistar rat liver. Method: Experimental study with post test only control group design used 24 wistar male adult rats which were divided into 4 groups. Group Kontrol received no acetaminophen, group P1 treated with 1200mg/kg weight acetaminophen, group P2 treated with 2400mg/kg weight acetaminophen, group P3 treated with 4800mg/kg weight acetaminophen. Result: Outcome of Kruskall Wallis test showed significant differences between all groups (p=0,000). Outcome of Mann Whitney test showed significant differences between all groups. The outcome was: Kontrol-P1 (p=0,006), Kontrol-P2 (p=0,008), Kontrol-P3 (p=0,008), P1-P2 (p=0,006), P1-P3 (p=0,006), P2-P3 (p=0,009). Conclusion: There were differences of histopathology appearance of wistar rat liver between untreated group and acetaminophen treated group. There were also differences histopathology appearance of wistar rat liver between variance dosage treated group, and hepatosit cell injury was rising along with the rise of acetaminophen dosage. Key Words: Acetaminophen, liver histopathology appearance