PENGARUH PEMBERIAN ASPIRIN DOSIS TOKSIK PER ORAL TERHADAP GAMBARAN HISTOPATOLOGI GASTER, DUODENUM, DAN JEJUNUM TIKUS WISTAR

Abstract

Background: Aspirin (acetylsalicylic acid) is known as non-steroidal anti-inflammatory drugs or NSAIDs and used in the treatment of mild to moderate pain. Aspirin is widely spread and sold over the counter for self medicating purposes, so that the probability of aspirin poisoning will be greater. Aspirin causes desquamation of surface epithelial cells and decreases the mucous secretion by particular mechanism of action: suppress the synthesis of prostaglandin and thromboxane. Side effects of aspirin especially perform at gastrointestinal tract. In common dosage the most serious effect is gaster’s disorder by irritating the gaster’s mucosa. Objective: Observing the histopathological appearance of Wistar’s gaster, duodenum, and jejunum after administered aspirin with toxic dosage. Method: This research was an experimental study with post test only with control group design. The samples were 12 Wistar male rats which were divided into two groups. The control group (K): with no treatment, treatment group (P): were given 3,15 mg/g BW. The significant differences between control group and treatment group were tested by using Independent t-test or Mann-Whitney test. Meanwhile the significant differences among the assessment of treatment group were tested by using Kruskal-Wallis test and then continued by Mann-Whitney test. Result: Independent t-test between group K and P with assessment at gaster and duodenum show significant difference (p = 0,000). In Mann-Whitney test between group K and P with assessment at jejunum also show significant difference (p = 0,019). In Kruskal-Wallis test between assessment of treatment group also show significant difference (p= 0,024), so it continues with Mann-Whitney test which only show significant difference between gaster and duodenum (p = 0,004). Conclusion: There were effects between administrating 3,15 mg/g BW aspirin to histopathological appearance of Wistar’s gaster, duodenum, and jejunum, and the worst damage was found in duodenum. The histopathological level changes were in the form of mucosal epithelial integrity. Keywords: Aspirin, mucosal epithelial integrity, Gaster, Duodenum, Jejunum.