PENGARUH PEMBERIAN MINYAK Pandanus conoideus (BUAH MERAH) TERHADAP PERUBAHAN DERAJAT ADENOKARSINOMA MAMMAE MENCIT C3H

Abstract

Background: Breast cancer is the second malignancy after carcinoma cervix. Pandanus conoideus believed as anti tumor. Pandanus conoideus oil contains high levels of betacarotene and tocopherol, which increase T-cell activity and limfosit B differentiation, so the growth of carcinoma cell can be inhibited. Objectives: Observing the effect of Pandanus conoideus oil to the histology grading of adenocarcinoma mammae C3H mice. Methods: This is an experimental study, using the post test only control group design make the samples were 15 C3H mice, randomized into 3 groups. Group K: were innoculated with cancer cells, got standard diet, and were given with 0,2 cc aquadest per day orally for 3 weeks. P1: were innoculated with cancer cells and then after tumors appeared, administrated with 0,2 cc Pandanus conoideus oil per day orally for 3 weeks. P2: were innoculated with cancer cells and then after tumors appeared for 3 weeks, administrated with 0,2 cc Pandanus conoideus oil per day orally for 3 weeks. Result: The highest mean score of histology grading occured in group K, followed by P1 and P2. the result of histological grading difference among all group is (p=0,008). The result between group K-P1 and K-P2 (p=0,007), and between group P1-P2(p=0,655). Conclusion: The administering of Pandanus conoideus oil could give effect to reduce histology grading significantly C3H mice. Keyword: Mice C3H, Pandanus conoideus, grading histologic.