PERBANDINGAN DOSIS INDUKSI KETAMIN 1 mg/KgBB DAN 2 mg/KgBB TERHADAP TEKANAN DARAH DAN FREKUENSI DENYUT JANTUNG

Abstract

Back ground: Ketamine is a general anesthetic drug with rapid work,which given intramuscularly or intravenously and may take a role as a monoanesthetic drug that cause analgesia, absent of conciousness, immobilitation.Until now ketamine is still broadly used especially given intravenously because it was save enough, easy administrated and several of indications. If it is given properly it will be very useful especially in the area with limited resources of facilities, budgets and expert in anaesthesiologist, but until now still become a question about the most accurate dose forgiving ketamin induction Objective: To define the effect of giving Ketamine induction dose of 1 mg/kgBW and 2 mg/kgBW to blood pressure and heart rate Material and methods: The methodology of study was Clinical trial with retrospective design.Conducted in February to June 2007. Secunder data was collected from Medical records of Dr.Kariadi General Hospital. Subjects consist of cases who were given general anaesthetic with intravenously with inclusion criterias.Subjects were divided in to 2 groups of Ketamine dose consist of 1 mg/kgBW i.v and 2 mg/kgBW i.v . Statistical analysis was used SPSS Version 15 by using distribution and frequency for categorical data. Mean and Standard deviation was used for continuum data. Changes of blood pressure and heart rate before and after induction was tested by using a paired t Test. Differentiation of blood pressure and heart rate between two groups was tested by using none paired t Test Results: Mean of Systolic pressure at early and 5 minutes after induction is higher in Group 2 than Group 1 and it was significantly different. (p=0,01)Mean of diastolic pressure at early and 5 minutes after induction in Group 2 is higher than Group 1 but is not significantly different . Mean delta of Changing of systolic pressure and diastolic pressure among 2 groups is not significantly different (p>0,01). Increasing of heart rate among 2 groups is not significantly different ( p>0,01) Conclusion: Induction of Ketamine with dose of 1 mg/kgBW and 2 mg/kgBW leads to increasing of blood pressure and heart rate but clinically still within normal limit. Key words : Ketamine intra venously , general anaesthetic, changing of blood pressure and heart rate .