PENGARUH KETOROLAK INTRA VENA TERHADAP KADAR KREATININ URIN ENAM JAM PASCA BEDAH DENGAN ANESTESI UMUM

Abstract

Background: Ketorolac is a potent agent from non steroidal anti inflammatory drugs (NSAIDs) family that frequently used in a combined analgesic. In reducing pain it inhibits prostaglandin synthesis. This lowering level of prostaglandin creates endogen vasoconstriction in renal arteries, followed by decreasing glomerular filtration rate (GFR). Decreasing GFR correlates with decreasing creatinine secretion since creatinine only secreted by kidney. The aim of this study is to find out how much IV ketorolac can decrease urine creatinine. Patients and Methods: This study is a 3rd phase of 2nd stage clinical trial with parallel design without matching, included 42 patients, divided into 2 groups using consecutive sampling and followed by block randomization. Samples were patients undergoing to elective surgery in Dr. Kariadi Hospital Semarang that fulfilling inclusion criteria that are: 16-40 years old, ASA physical status I-II, using general anesthesia, length of operation 2-3 hours, no contra indication for anesthetic agent, normal weight (Brocca 90%-110%); and not fulfilling exclusion criteria that are: having muscle, heart, or kidney diseases, and those that are cured with cimetidine, isoniazid, or gentamicin. The collected data for this study consist of demographics data and urine creatinine before and after operation. The data normality test was Shapiro-Wilk. Result: The demographics and urine creatinine before operation data of ketorolac group and control group revealed no significant differences so that both group can be compared. The result of this study indicated that there were significant changes at urine creatinine in ketorolac group but no significant changes if we compared it with control group. Conclusion: Thirty milligrams of ketorolac tromethamine intravenous decreases urine creatinine in patient with general anesthesia but it is not significant changes if compared with control. Keywords: anesthesia, ketorolac, urine creatinine