GAMBARAN BESI SERUM, KAPASITAS IKAT BESI TOTAL DAN FERITIN SERUM PADA PENDERITA DEMAM TIFOID

Abstract

BACKGROUND :Typhoid f ver is an endemic disease in Indonesia with a high morbidity and mortality, with a potential of becoming an outbreak. Typhoid fever is an acute systemic illness caused by infection with s lmonella typhi. Paratyphoid fever is a clicically and pathologically rather similar, but generally milder illness that caused by Salmonella paratyphi. Infection is a situation where iron met bolism is disturbed. The specific Iron metabolism pattern in infections are the decrea e of serum iron concentration,TIBC dan transferin saturation, whereas ferritin serum concentration will rise, so it does not reflect the body iron status. METHOD : Cross sectional study, descriptive. RESULTS : 30 respondent and 50 years old, with the was 39.11 ug/dI (SD ± 21.E respondents (66.33%).The (SD ± 45.9), and were lo was 16% (SD ± 6.66%) an ferritin was 1329 ng/ml (S had a high serum ferritin cc , 16 male and 14 female were studied, ages ranging between 15 highest in the 15-20 year-old group. The male mean serum iron ), female 35.12 ug/dI (SD ± 17.4) and were low in the most of the mean male TIBC was 253.8% ug/dI (SD ± 77), female 222.1 ug/dI in most respondents (73.33%), The mean transferin saturation i were low in most respondents (78.66%). The mean male serum ± 496), female 1324 ng/ml (SD ± 411), all respondents (100%) ncentration. CONCLUSION : The stud: transferin saturation, but a patients does not indicate high body iron status. showed a pattern of low serum iron concentration, TIBC and high serum ferritin concentration. Hypoferremia in typhoid fever in iron deficiency, and hyperferritinemia also does not indicate a Latarbelakang : D morbiditas dan mortalitas adalah suatu penyakit s merupakan salah satu kea yang khas metabolisme be saturasi transferin menu mencerminkan status best t mam tifoid merupakan penyakit endemis di Indonesia dengan ang tinggi, serta berpotensi menimbulkan wabah. Demam tifoid stemik akut yang disebabkan infeksi salmonela tiff. Infeksi aan yang dapat mengganggu metabolisme zat best tubuh. Pola i tubuh pada keadaan infeksi adalah kadar Fe serum, TIBC dan n, sedangkan kadar feritin serum meningkat sehingga tidak buh sebenarnya. Hasil penelitian : Dit liti sebanyak 30 responden, 16 responden laki laki dan 14 responden perempuan, d ngan umur berkisar antara 15 - 50 tahun, terbanyak adalah kelompok umur 15 - 20 tah n. Rerata Fe serum laki laki 39,11 ug/dI (SD ± 21,6), perempuan 35,12 ug/c11 (SD ± 17,4). Kadar Fe serum sebagian besar (66,33%) responden adalah rendah. Rerata TIBC laki I ki 253,8% ug/dI (SD ± 77). perempuan 222,1 ug/dI (SD ± 45,9). TIBC sebagian besar (7 ,33%) responden adalah rendah. Rerata prosentase saturasi transferin responden adala 16% (SD ± 6,66). Prosentase saturasi transferin sebagian besar (76,66%) responden adala rendah. Rerata feritin serum laki laki 1329 ng/ml (SD ± 496), perempuan 1324 ng/ml (SD .± 411). Semua responden (100%) mempunyai kadar feritin serum yang tinggi. Kesimpulan : Ga penderita demam tifoid ad kadarteritin serum tinggi. karena defisiensi besi, seb cadangan besi tubuh. baran kadar Fe serum, TIBC, saturasi transferin dan feritin serum lah Fe serum, TIBC dan saturasi transferin rendah sedangkan ipoferemia pada penderita demam tifoid belum tentu disebabkan liknya hiperferitinemia belum tentu disebabkan karena tingginya