PENGARUH PEMBERIAN PROPOXUR DOSIS BERTINGKAT PER ORAL TERHADAP GAMBARAN HISTOLOGI DUODENUM MENCIT BALB/c

Abstract

Background: There are about 300.000.000 cases of serious intoxication worldwide because of pesticide with more than 220.000 death every year. From many kind of pesticide, the carbamat group are one of the kind that often used for suicide purpose. Some scientist reveal that pesticide from this group if used, will be distributed quickly to organ and tissue. Objective: The objective of this experiment is to examine and to score the histological appearance of Balb/c mice small intestine given oral administration of graded dose Propoxur. Method: The experiment used The post test only control group design. There are 4 groups with 6 sample of mice each groups so there are total of 24 Balb/c male mice, with age of 6-8 weeks and weight of 20-25 gram. K is the control group, without being given any Propoxur. P1 is mice being given Propoxur orally 1/2x37mg/KgBW (1/2 of lethal dose). P2 is mice being given Propoxur orally 37mg/KgBW (lethal dose). P3 is mice being given Propoxur orally 2x37mg/KgBW (2x of lethal dose). The differential test between groups and control are using the Kruskal-Wallis and Mann-Whitney test. Result: The average score of epitelial integrity from the four groups are significant. The average score of epitelial integrity for group K are the smallest per high microscopal resolution, (0,16 + 0,41). And the bigest average score of epitelial integrity is the P3 group (2,83 + 0,41). The average score of epitelial integrity between control and P1 are significant (p=0,006), control with P2 (p=0,002), control with P3 (p=0,002), P1 with P2 (p=0,018), P1 with P3 (p=0,004), P2 with P3 (p=0,027). Conclusion: The Propoxur given orally with graded doses are significantly affects the damage done to the epitelial mucose of Balb/c mice small intestine. Keywords: Propoxur, small intestine, the integrity of epitelial mucose.