GAMBARAN HISTOPATOLOGI GASTER MENCIT BALB/C PADA PEMBERIAN ARSEN TRIOKSIDA DOSIS BERTINGKAT PERORAL

Abstract

Background: Arsenic is widely used as a part of industrial and commercial products, Pharmaceutical components and as intended toxic agents. Toxicity effects caused by this agent are various starting from systemic effect, neurological effect, cancer even death. Death effect occurs when tissues absorb arsenic over the tolerated dosage, Causing gastrointestinal tracts damage, fluid loss and vascular collapse. Pathogenesis of acute gastritis is mostly caused by the mucosal irritation caused the trioxide arsenic. Method : This research was experimental using The post test only control group design. There were four group with number of sample were 4, so that the total was 24 of 8-10 weeks Balb/c mice’s with weight of 20-25 g. K was the control without given arsenic trioxide. P1 was given arsenic trioxide 11 mg (½lethal dosage). P2 was given 22 mg (2x lethal dosage). P3 was given 44 mg ( 2x lethal dosage). The significantly was tested by using Kruskal-Wallis test and Mann Whitney test. Result: Mean score of epithelial integrity of stomach from four groups was significantly different ( P=0,002 ). Mean score of epithelial integrity of stomach from P1 was the lowest (2,17 + 0,41) and P3 is the highest(2,83+ 0,41). Mean score of epithelial interity of stomach between control and P1 was significant (p=0,006), control and P2 was significant (p=0,005), control and P3 was significant (p=0,002), and P1 and P3 was significant (p=0,0241). P3 had the highest median, and the lowest is the control group. Conclusion: With the increase of Arsenic Trioxide dosage there was a significant difference the histopathological pattern of the mice’s stomach of BALB/c in the form of mucous epithelial damage that also increase between the group that were given arsenic trioxide and that who was not. Keywords: Arsenic Trioxide, the Stomach, mucous epithelial integrity.