PENGARUH EKSTRAK DAUN Apium graviolens TERHADAP PERUBAHAN SGOT/SGPT TIKUS WISTAR JANTAN YANG DIPAPAR KARBON TETRAKLORIDA

Abstract

Background: Flavonoid is an antioxidant which can be found in celery (Apium graviolens). It is assumed that flavonoid has hepatoprotector effect. The purpose of this research is to verify the effect of flavonoid to liver function in male wistar applied with carbon tetrachloride. Method: This is an experimental study, using the post test only control group design. The samples were 20 male wistars which divided into 2 groups. The control group, 10 rats, given standard diet for a week then applied with carbon tetrachloride in the 8th day. The treatment group, 10 rats, given standard diet plus celery extract for a week then applied with carbon tetrachloride in the 8th day. The data obtained from this study was the changes of SGOT/SGPT level. Using the Kolmogorov-Smirnov test, the distribution was abnormal (p<0,05) so non parametric test was chosen (Mann-Whitney test). The result of Mann-Whitney test showed a significant difference (p<0,01). Result: From the control group, the changes of SGOT level was 474,50 and the changes of SGPT level was 709,40. From the treatment group, the changes of SGOT level was 159,70 and the changes of SGPT level 283,10. Conclusion: Apium graviolens leaves extract can affect the changes of SGOT/SGPT level in male wistar applied with carbon tetrachloride. Key word : male wistar rats, carbon tetrachloride, Apium graviolens, the changes of SGOT/SGPT