PERBEDAAN JUMLAH RETIKULOSIT TROMBOSIT PADA PREPARAT DARAH APUS PASIEN DEMAM BERDARAH DENGUE DIBANDING ORANG NORMAL

Abstract

Background : Reticulated platelets are platelets which still have RNA in their bodies and can be count on blood smear examination. The percentage of reticulated platelets is equal with the examination of megakaryocyte in bone marrow for thrombopoietic evaluation. An elevating numbers of reticulated platelets in blood smear examination indicate an elevating thrombopoietic process in the bone marrow. The evaluation of platelets in Dengue Hemorrhagic Fever (DHF) is very important to diagnose and observe the patient. By examining the numbers of reticulated platelets, we could know bone marrow response to thrombocytopenia in DHF. Method : This study was descriptive analytic research with a cross sectional approach. Sample was divided into 2 groups. Group I was 32 normal persons and Group II was 32 Dengue Hemorrhagic Fever patient. The numbers of platelets was count using the automatic hematology analyzer and the numbers of reticulated platelets in blood smear examination using Barbara Brown method. Results : The mean numbers of reticulated platelets in Group I was 19,200 ± 1,623.36 / mm3 and the mean numbers of reticulated platelets in Group II was 24,000 ± 16,059.86mm3. The percentage of reticulated platelets in Group I was 7.76 ± 1.64 %, group II was 44.93± 39.46 % Conclusion : This research shows a significant elevating numbers (p<0,05) of reticulated platelets count on blood smear examination on Dengue Hemorrhagic Fever patients compared with normal persons which are correlates with a good thrombopoietic response of bone marrow’s patient. Key Words : Reticulated Platelets, Thrombocytopenia, Dengue Hemorrhagic Fever (DHF).