POLA KUMAN PADA KULTUR DARAH DAN KEPEKAANNYA TERHADAP SEFOTAKSIM DAN AMIKASIN SERTA FAKTOR-FAKTOR YANG MEMPENGARUHINYA DI RUANG HIGH NURSING DEPENDENCY (HND) DAN NON-HND BANGSAL ANAK

Abstract

Background: Infection therapy for children needs antibiotics. Since penicillin resistence already high, doctors tend to give second line drug, like cefotaxim, for initial therapy especially in HND so that its resistence tends to increase. The objectives of this study were to observe the difference of bacterial pattern and its sensitivity to cefotaxim and amikacin and to observe factors influencing bacterial pattern in HND and non-HND patients of Pediatric Ward at Kariadi Hospital. Method: Data were collected retrospectively from medical records of Pediatric Ward at Kariadi Hospital in year 2004. Statistic analysis used are X2 and logistic regression test. Results: Three major bacteria causing bacteremia were Enterobacter spp, Pseudomonas aeruginosa, and Staphylococcus epidermidis. There were no significant differences of bacterial pattern (p=0,054).Bacteria in HND room less sensitive to cefotaxim than those in non-HND room(p=0,014). Amikacin sensitivity, in both nursing room, did not significantly differ(p=0,13). Age,length of stay, invasive procedures, complications, nursing room, and cefotaxim initial affected bacterial pattern. Length of stayand nursing room affected cefotaxim sensitivity. Amikacin sensitivity was affected by length of stay. Conclusion: Cefotaxim sensitivity in HND room less sensitive than in non-HND room. Keyword: infection, initial antibiotics therapy, amikacin, cefotaxim.