UJI BANDING EFEKTIVITAS KUNYIT ( CURCUMA LONGA LINN ) 100% DENGAN KETOKONAZOL 2% SECARA INVITRO TERHADAP PERTUMBUHAN Candida albicans PADA KANDIDIASIS VAGINALIS

Abstract

Background : Vaginal candidiasis is a fungal infection which cause of Candida albicans. Ketoconazole, antifungal potential for vaginal candidiasis. Turmeric (Curcuma longa Linn) is a traditional drug for vaginal candidiasis. Objective : To compare the effectiveness of 100% turmeric ( Curcuma longa Linn ) with 2% ketoconazole in vitro to the growth of Candida albicans in vaginal candidiasis. Method : This study was an experimental analytic. Samples from 10 patients who fulfilled clinical signs of vaginal candidiasis. From microscopically, if (+) Candida inoculated on the SDA + chloramphenicol 50 μg/ml medium at 370C for 2 days. The colonies which grow is done germ tube test, if (+) Candida albicans diluted in 0,9 % NaCl make equal to 0,5 Mc Farland’s standard. Put 0,1 ml of solution and cultivated on SDA + 100% turmeric ( Curcuma longa Linn ) and 2% ketoconazole. Every sample was replicated three times, then incubated at 370C for 2 days. Analyzed by chi square test. Result : 30 SDA + 100% turmeric ( Curcuma longa Linn ), 29 positive growth and 1 negative Candida albicans. Meanwhile, 30 media contained 2% ketoconazole, 15 positive and 15 negative. The result of the chi square test is significant, p= 0.000 (p<0,05). Conclusion : 100% turmeric was proved less effective in hindering the growth of Candida albicans compare with 2% ketokonazol. Key words : Vaginal candidiasis, Candida albicans, 2% ketoconazole, 100% Turmeric (Curcuma longa Linn)