Pengaruh Pemberian Ekstrak Batang Tinospora crispa Dibandingkan dengan Klorokuin Terhadap Tingkat Parasitemia Mencit Swiss Yang Diinfeksi Plasmodium berghei

Abstract

Background: Tinospora crispa (brotowali) is an advantageous herbal. Tinocrisposid, the most important substance on its stem used as antimalaria, hoped can reduce the parasite level of Swiss mice infected by Plasmodium berghei. The aim: To compare the effect on parasite level of Swiss mice infected by Plasmodium berghei between giving Tinospora crispa and chloroquine. Method: Research design, Pre and Post Test Control Group Design with 18 mice, divided into 3 groups, K (Control), P1 (given chloroquine), P2 (given Tinospora crispa). All were infected by 104 Plasmodium berghei at a 1st day. At 3rd to 5th day, P1 and P2 each were given chloroquine and Tinospora crispa. From the 1st day post infection until 1 day post therapy, some peripheral-blood samples taken for making the preparat. Analyzed data with Kruskal Wallis test and Mann-Whitney test Result: A substantial difference in the parasites amount between K and P1 on 4th to 7th day. A substantial difference between K and P2 on 5th to 7th day. There is no substantial difference between P1 and P2. Conclusions: There is no substantial difference of parasite amounts in the Swiss mice infected with Plasmodium berghei between given by Tinospora crispa stem’s extract and Chloroquine. Key Words: Tinospora crispa, Chloroquine, Parasites amount, Parasite level reduction