SINTESIS SENYAWA ANTIINFLAMASI FLAVONOID MENGGUNA KAN ASAM SINAMAT SEBAGAI BAHAN DASAR

Abstract

Reaction on Fries rearrangement by used catalyst AICE anhidrous has been conducted to phenyl cinnamic. Reaction was carried out at 100 °C for two hours. Based on the resulting analysis by UV-Vis and infra red spectrophotometer, it was known thai reaction of Fries rearrangement has been gone. From the result of synthesis was obtained two compounds are para-hydroxy chalcone and flavanone, which result of isomerization from ono-hidroxy chal cone.Reaksi penataan Wang Fries dengan menggunakan katalis A1C13 anhidrat telah dilakukan terhadap senyawa fenil sinamat. Reaksi berlangsung pada temperatur 100 °C selama 2 jam. Analisis produk reaksi dengan rnenggunakan spektrofotometer UV-Vis dan infra merah, mengindikasikan bahwa reaksi penataan ulang Fries telah berlangsung. Dafi hasil sintesis didapatkan dua senyawa yaitu para-hidroksi kalkon dan Amnon yang merupakan hasil isomerisasi dad orto-hidroksi Lai Icon